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SIX2

GENERAL INFORMATION

Gene name

 SIX2

Gene description

 SIX homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cervix, uterine, salivary gland, parathyroid gland, skeletal muscle, prostate)
GTEx:Tissue enhanced (skeletal muscle, pituitary gland)
FANTOM5:Tissue enhanced (salivary gland, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA052782
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, salivary gland, parathyroid gland, skeletal muscle, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, pituitary gland)

GENE INFORMATION

Gene name

 SIX2

Synonyms

Description

 SIX homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 45005161 - 45009430

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170577 (version 83.38)

Entrez gene

 10736

UniProt

 Q9NPC8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPC8

Antibodypedia

 SIX2 antibodies

PROTEIN BROWSER
SIX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIX2-001
ENSP00000304502
ENST00000303077
Q9NPC8 [Direct mapping]
Homeobox protein SIX2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001656 [metanephros development]
GO:0001822 [kidney development]
GO:0002062 [chondrocyte differentiation]
GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006606 [protein import into nucleus]
GO:0007501 [mesodermal cell fate specification]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009948 [anterior/posterior axis specification]
GO:0016477 [cell migration]
GO:0030278 [regulation of ossification]
GO:0031965 [nuclear membrane]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032403 [protein complex binding]
GO:0042474 [middle ear morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045596 [negative regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0072006 [nephron development]
GO:0072028 [nephron morphogenesis]
GO:0072038 [mesenchymal stem cell maintenance involved in nephron morphogenesis]
GO:0072161 [mesenchymal cell differentiation involved in kidney development]
GO:0090189 [regulation of branching involved in ureteric bud morphogenesis]
GO:0097168 [mesenchymal stem cell proliferation]
GO:1902732 [positive regulation of chondrocyte proliferation]
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 291 aa
32.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.