Tissue expression of SLC26A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC26A5
Gene description	Solute carrier family 26 (anion exchanger), member 5
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (urinary bladder)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (urinary bladder)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	SLC26A5 (HGNC Symbol)
Synonyms	DFNB61, PRES
Description	Solute carrier family 26 (anion exchanger), member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	103352730 - 103446177
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000170615 (version 83.38)
Entrez gene	375611
UniProt	P58743 (UniProt - Evidence at transcript level)
neXtProt	NX_P58743
Antibodypedia	SLC26A5 antibodies

PROTEIN BROWSER

SLC26A5-001	SLC26A5-002	SLC26A5-003	SLC26A5-004	SLC26A5-008	SLC26A5-009	SLC26A5-010	SLC26A5-013	SLC26A5-201	SLC26A5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC26A5-001 ENSP00000304783 ENST00000306312	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0002931 [response to ischemia] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008134 [transcription factor binding] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0009751 [response to salicylic acid] GO:0010996 [response to auditory stimulus] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0015755 [fructose transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0030507 [spectrin binding] GO:0034220 [ion transmembrane transport] GO:0034766 [negative regulation of ion transmembrane transport] GO:0035864 [response to potassium ion] GO:0042391 [regulation of membrane potential] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0045793 [positive regulation of cell size] GO:0051262 [protein tetramerization] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0090102 [cochlea development] GO:0097066 [response to thyroid hormone] GO:0098656 [anion transmembrane transport] GO:1902074 [response to salt] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:2000147 [positive regulation of cell motility] Show all	744 aa 81.3 kDa	No	>9
SLC26A5-002 ENSP00000342396 ENST00000339444	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	685 aa 74.8 kDa	No	>9
SLC26A5-003 ENSP00000349210 ENST00000356767	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	335 aa 36.9 kDa	No	7
SLC26A5-004 ENSP00000377336 ENST00000393735	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	516 aa 56.5 kDa	No	>9
SLC26A5-008 ENSP00000377331 ENST00000393730	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	712 aa 77.6 kDa	No	>9
SLC26A5-009 ENSP00000377328 ENST00000393727	Q7Z7F4 [Direct mapping] Prestin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015116 [sulfate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902358 [sulfate transmembrane transport] Show all	746 aa 81.5 kDa	No	>9
SLC26A5-010 ENSP00000377324 ENST00000393723	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	714 aa 77.8 kDa	No	>9
SLC26A5-013 ENSP00000377330 ENST00000393729	E9PCM2 [Direct mapping] Prestin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015116 [sulfate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902358 [sulfate transmembrane transport] Show all	707 aa 77.2 kDa	No	9
SLC26A5-201 ENSP00000346325 ENST00000354356	Q7Z7F4 [Direct mapping] Prestin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015116 [sulfate transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902358 [sulfate transmembrane transport] Show all	746 aa 81.5 kDa	No	>9
SLC26A5-202 ENSP00000389733 ENST00000432958	P58743 [Direct mapping] Prestin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0008360 [regulation of cell shape] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015701 [bicarbonate transport] GO:0016021 [integral component of membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	712 aa 77.6 kDa	No	>9