Cell atlas - SOCS6 - The Human Protein Atlas

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SOCS6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SOCS6
Gene description	Suppressor of cytokine signaling 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB010189
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

Nuclear speckles (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010189	A-431	Nuclear speckles
	CAB010189	A549	Nuclear speckles
	CAB010189	A549	Cytosol
	CAB010189	U-2 OS	Nuclear speckles
	CAB010189	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SOCS6 (HGNC Symbol)
Synonyms	CIS4, Cish4, HSPC060, SOCS4, SSI4, STAI4, STATI4
Description	Suppressor of cytokine signaling 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q22.2
Chromosome location (bp)	70288901 - 70330200
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170677 (version 83.38)
Entrez gene	9306
UniProt	O14544 (UniProt - Evidence at protein level)
neXtProt	NX_O14544
Antibodypedia	SOCS6 antibodies

PROTEIN BROWSER

SOCS6-001	SOCS6-002	SOCS6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOCS6-001 ENSP00000381034 ENST00000397942	O14544 [Direct mapping] Suppressor of cytokine signaling 6 A0A024R379 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 6, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0006952 [defense response] GO:0007259 [JAK-STAT cascade] GO:0010498 [proteasomal protein catabolic process] GO:0016567 [protein ubiquitination] GO:0019221 [cytokine-mediated signaling pathway] GO:0035556 [intracellular signal transduction] GO:0040008 [regulation of growth] GO:0046426 [negative regulation of JAK-STAT cascade] GO:0050868 [negative regulation of T cell activation] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	535 aa 59.5 kDa	No	0
SOCS6-002 ENSP00000463395 ENST00000582322	O14544 [Direct mapping] Suppressor of cytokine signaling 6 A0A024R379 [Target identity:100%; Query identity:100%] Suppressor of cytokine signaling 6, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0004860 [protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006469 [negative regulation of protein kinase activity] GO:0006952 [defense response] GO:0007259 [JAK-STAT cascade] GO:0010498 [proteasomal protein catabolic process] GO:0016567 [protein ubiquitination] GO:0019221 [cytokine-mediated signaling pathway] GO:0035556 [intracellular signal transduction] GO:0046426 [negative regulation of JAK-STAT cascade] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	535 aa 59.5 kDa	No	0
SOCS6-003 ENSP00000463064 ENST00000578377	J3KTM7 [Direct mapping] Suppressor of cytokine-signaling 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004860 [protein kinase inhibitor activity] GO:0006469 [negative regulation of protein kinase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0046426 [negative regulation of JAK-STAT cascade] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	227 aa 25 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.