Cell atlas - KCNS3 - The Human Protein Atlas

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KCNS3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Plasma membrane

Human cell
	Cytosol
	Golgi Apparatus
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KCNS3
Gene description	Potassium voltage-gated channel, modifier subfamily S, member 3
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane & the Golgi apparatus.
RNA cell category	Cell line enhanced (RH-30, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Golgi apparatus (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014864
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane & the Golgi apparatus.

Main location

Cytosol (approved)

Additional location

Golgi apparatus (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014864	A-431	Golgi apparatus
	HPA014864	A-431	Cytosol
	HPA014864	U-2 OS	No staining
	HPA014864	U-251 MG	Plasma membrane
	HPA014864	U-251 MG	Cytosol

GENE INFORMATION
Gene name	KCNS3 (HGNC Symbol)
Synonyms	Kv9.3
Description	Potassium voltage-gated channel, modifier subfamily S, member 3 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	2
Cytoband	p24.2
Chromosome location (bp)	17877847 - 18361616
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170745 (version 83.38)
Entrez gene	3790
UniProt	Q9BQ31 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ31
Antibodypedia	KCNS3 antibodies

PROTEIN BROWSER

KCNS3-001	KCNS3-002	KCNS3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNS3-001 ENSP00000305824 ENST00000304101	Q9BQ31 [Direct mapping] Potassium voltage-gated channel subfamily S member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	491 aa 56 kDa	No	6
KCNS3-002 ENSP00000385968 ENST00000403915	Q9BQ31 [Direct mapping] Potassium voltage-gated channel subfamily S member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	491 aa 56 kDa	No	6
KCNS3-003 ENSP00000400098 ENST00000419802	C9J187 [Direct mapping] Potassium voltage-gated channel subfamily S member 3 Show all	Predicted intracellular proteins Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0071805 [potassium ion transmembrane transport] Show all	74 aa 8.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.