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GPR37

GENERAL INFORMATION

Gene name

 GPR37

Gene description

 G protein-coupled receptor 37 (endothelin receptor type B-like)

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, testis)
GTEx:Tissue enhanced (hippocampus, caudate)
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Expressed in neuronal processes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA068009
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 GPR37 (HGNC Symbol)

Synonyms

 EDNRBL, hET(B)R-LP, PAELR

Description

 G protein-coupled receptor 37 (endothelin receptor type B-like) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Chromosome

 7

Cytoband

 q31.33

Chromosome location (bp)

 124745997 - 124765627

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170775 (version 83.38)

Entrez gene

 2861

UniProt

 O15354 (UniProt - Evidence at protein level)

neXtProt

 NX_O15354

Antibodypedia

 GPR37 antibodies

PROTEIN BROWSER
GPR37-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR37-001
ENSP00000306449
ENST00000303921
O15354 [Direct mapping]
Prosaposin receptor GPR37
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000151 [ubiquitin ligase complex]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0016021 [integral component of membrane]
GO:0030544 [Hsp70 protein binding]
GO:0031072 [heat shock protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031987 [locomotion involved in locomotory behavior]
GO:0036505 [prosaposin receptor activity]
GO:0042277 [peptide binding]
GO:0042416 [dopamine biosynthetic process]
GO:0043235 [receptor complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045964 [positive regulation of dopamine metabolic process]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
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 613 aa
67.1 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.