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CEL

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GENERAL INFORMATION

Gene name

 CEL

Gene description

 Carboxyl ester lipase

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CEL (HGNC Symbol)

Synonyms

 BSSL, MODY8

Description

 Carboxyl ester lipase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.13

Chromosome location (bp)

 133061978 - 133087355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170835 (version 83.38)

Entrez gene

 1056

UniProt

neXtProt

Antibodypedia

 CEL antibodies

PROTEIN BROWSER
CEL-001
CEL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEL-001
ENSP00000361151
ENST00000372080
X6R868 [Direct mapping]
Carboxylic ester hydrolase
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004622 [lysophospholipase activity]
GO:0004771 [sterol esterase activity]
GO:0004806 [triglyceride lipase activity]
GO:0005615 [extracellular space]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0032403 [protein complex binding]
GO:0042572 [retinol metabolic process]
GO:0042588 [zymogen granule]
GO:0043208 [glycosphingolipid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0046514 [ceramide catabolic process]
GO:0050253 [retinyl-palmitate esterase activity]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 756 aa
79.7 kDa 		Yes 0
CEL-201
ENSP00000480238
ENST00000621209
Q14018 [Direct mapping]
Bile salt-activated lipase; Carboxyl ester lipase (Bile salt-stimulated lipase), isoform CRA_a; Carboxyl ester lipase-like protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
 59 aa
6.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.