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Cancer tissues displayed moderate cytoplasmic positivity. A few hepatocellular carcinomas showed strong staining. Several carcinoids, gliomas and cervical cancers were weakly stained.
GENE INFORMATION
Gene name
TRIAP1 (HGNC Symbol)
Synonyms
HSPC132, MDM35, P53CSV, WF-1
Description
TP53 regulated inhibitor of apoptosis 1 (HGNC Symbol)
O43715 [Direct mapping] TP53-regulated inhibitor of apoptosis 1
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Transporters Primary Active Transporters Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0015914 [phospholipid transport] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0034644 [cellular response to UV] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048471 [perinuclear region of cytoplasm] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097035 [regulation of membrane lipid distribution] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1990050 [phosphatidic acid transporter activity] GO:2001140 [positive regulation of phospholipid transport]