Tissue expression of OSCAR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	OSCAR
Gene description	Osteoclast associated, immunoglobulin-like receptor
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, bone marrow)
GTEx:	Group enriched (spleen, lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	OSCAR
Synonyms
Description	Osteoclast associated, immunoglobulin-like receptor (HGNC Symbol)
Entrez gene summary	Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54094668 - 54102692
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170909 (version 83.38)
Entrez gene	126014
UniProt	Q8IYS5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IYS5
Antibodypedia	OSCAR antibodies

PROTEIN BROWSER

OSCAR-001	OSCAR-002	OSCAR-004	OSCAR-005	OSCAR-006	OSCAR-007	OSCAR-008	OSCAR-201	OSCAR-202	OSCAR-203	OSCAR-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSCAR-001 ENSP00000365808 ENST00000284648	Q8IYS5 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	282 aa 30.5 kDa	Yes	0
OSCAR-002 ENSP00000352671 ENST00000359649	A0A087WV17 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	286 aa 30.9 kDa	Yes	0
OSCAR-004 ENSP00000351145 ENST00000358375	A0A0A0MRF2 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	263 aa 28.8 kDa	Yes	1
OSCAR-005 ENSP00000348927 ENST00000356532	A0A087X1R2 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	267 aa 29.2 kDa	Yes	1
OSCAR-006 ENSP00000304523 ENST00000351806	A0A0A0MR14 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	252 aa 27.6 kDa	Yes	1
OSCAR-007 ENSP00000375640 ENST00000391760	A8MWV3 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 16.4 kDa	Yes	0
OSCAR-008 ENSP00000375641 ENST00000391761	Q8IYS5 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	271 aa 29.3 kDa	Yes	0
OSCAR-201 ENSP00000479089 ENST00000611261	A0A087WV17 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	286 aa 30.9 kDa	Yes	0
OSCAR-202 ENSP00000479628 ENST00000616215	Q8IYS5 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	271 aa 29.3 kDa	Yes	0
OSCAR-203 ENSP00000483558 ENST00000616447	A0A087X0P3 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	268 aa 29.3 kDa	Yes	1
OSCAR-204 ENSP00000484401 ENST00000617140	A0A087X1R2 [Direct mapping] Osteoclast-associated immunoglobulin-like receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	267 aa 29.2 kDa	Yes	1