Expression of PGK2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphoglycerate kinase 2

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045385

GENE INFORMATION
Gene name	PGK2 (HGNC Symbol)
Synonyms	PGK-2, PGKPS
Description	Phosphoglycerate kinase 2 (HGNC Symbol)
Entrez gene summary	This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	49785651 - 49787307
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170950 (version 83.38)
Entrez gene	5232
UniProt	P07205 (UniProt - Evidence at protein level)
neXtProt	NX_P07205
Antibodypedia	PGK2 antibodies

PROTEIN BROWSER

PGK2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGK2-001 ENSP00000305995 ENST00000304801	P07205 [Direct mapping] Phosphoglycerate kinase 2 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004618 [phosphoglycerate kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006096 [glycolytic process] GO:0016310 [phosphorylation] GO:0030317 [sperm motility] GO:0035686 [sperm fibrous sheath] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	417 aa 44.8 kDa	No	0