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HAS2

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GENERAL INFORMATION

Gene name

 HAS2

Gene description

 Hyaluronan synthase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles.

RNA cell category

 Cell line enhanced (U-138 MG, LHCN-M2, HBF TERT88, U-251 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA052060
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG, LHCN-M2, HBF TERT88, U-251 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles.

Main location

 Nuclear speckles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA052060 RH-30 Nucleoplasm
HPA052060 U-2 OS Nuclear speckles
Cytosol
HPA052060 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 HAS2

Synonyms

Description

 Hyaluronan synthase 2 (HGNC Symbol)

Entrez gene summary

 Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.13

Chromosome location (bp)

 121612116 - 121641390

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170961 (version 83.38)

Entrez gene

 3037

UniProt

 Q92819 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92819

Antibodypedia

 HAS2 antibodies

PROTEIN BROWSER
HAS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAS2-001
ENSP00000306991
ENST00000303924
Q92819 [Direct mapping]
Hyaluronan synthase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0001570 [vasculogenesis]
GO:0001822 [kidney development]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0008284 [positive regulation of cell proliferation]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030335 [positive regulation of cell migration]
GO:0035810 [positive regulation of urine volume]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0036302 [atrioventricular canal development]
GO:0044849 [estrous cycle]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0051549 [positive regulation of keratinocyte migration]
GO:0060349 [bone morphogenesis]
GO:0070295 [renal water absorption]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071498 [cellular response to fluid shear stress]
GO:0085029 [extracellular matrix assembly]
GO:0090500 [endocardial cushion to mesenchymal transition]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900127 [positive regulation of hyaluronan biosynthetic process]
GO:1900625 [positive regulation of monocyte aggregation]
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 552 aa
63.6 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.