Expression of LRRC8E in cancer - Summary

CANCER ATLAS

Gene description

Leucine rich repeat containing 8 family, member E

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA020466

GENE INFORMATION
Gene name	LRRC8E (HGNC Symbol)
Synonyms	FLJ23420
Description	Leucine rich repeat containing 8 family, member E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7888505 - 7902021
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171017 (version 83.38)
Entrez gene	80131
UniProt	Q6NSJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NSJ5
Antibodypedia	LRRC8E antibodies

PROTEIN BROWSER

LRRC8E-001	LRRC8E-002	LRRC8E-003	LRRC8E-004	LRRC8E-005	LRRC8E-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC8E-001 ENSP00000306524 ENST00000306708	Q6NSJ5 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] Show all	796 aa 90.2 kDa	No	4
LRRC8E-002 ENSP00000470302 ENST00000598224	M0QZ48 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21.3 kDa	No	2
LRRC8E-003 ENSP00000472491 ENST00000599367	M0R2D8 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	137 aa 16 kDa	No	2
LRRC8E-004 ENSP00000473127 ENST00000600345	M0R3C1 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 7.7 kDa	No	0
LRRC8E-005 ENSP00000472642 ENST00000593511	M0R2K8 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	95 aa 10.8 kDa	No	1
LRRC8E-201 ENSP00000479953 ENST00000618098	Q6NSJ5 [Direct mapping] Volume-regulated anion channel subunit LRRC8E Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] Show all	796 aa 90.2 kDa	No	4