Cell atlas - SOX7 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SOX7
Gene description	SRY (sex determining region Y)-box 7
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HUVEC TERT2, TIME, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA009065
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, TIME, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear speckles (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA009065	A-431	Nuclear speckles
HPA009065	A-431	Golgi apparatus
HPA009065	PC-3	Nuclear speckles
HPA009065	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	SOX7
Synonyms
Description	SRY (sex determining region Y)-box 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	10723768 - 10730512
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171056 (version 83.38)
Entrez gene	83595
UniProt	Q9BT81 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BT81
Antibodypedia	SOX7 antibodies

PROTEIN BROWSER

SOX7-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOX7-001 ENSP00000301921 ENST00000304501	Q9BT81 [Direct mapping] Transcription factor SOX-7 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Show all	GO:0001706 [endoderm formation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008285 [negative regulation of cell proliferation] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060828 [regulation of canonical Wnt signaling pathway] Show all	388 aa 42.2 kDa	No	0