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KCNMB3

CANCER ATLAS

Gene description

 Potassium channel subfamily M regulatory beta subunit 3

Protein class

 Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015665
HPA019185

GENE INFORMATION

Gene name

 KCNMB3 (HGNC Symbol)

Synonyms

 KCNMB2, KCNMBL

Description

 Potassium channel subfamily M regulatory beta subunit 3 (HGNC Symbol)

Entrez gene summary

 MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

Chromosome

 3

Cytoband

 q26.32

Chromosome location (bp)

 179236691 - 179267002

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171121 (version 83.38)

Entrez gene

 27094

UniProt

 Q9NPA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPA1

Antibodypedia

 KCNMB3 antibodies

PROTEIN BROWSER
KCNMB3-001
KCNMB3-002
KCNMB3-004
KCNMB3-005
KCNMB3-006
KCNMB3-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNMB3-001
ENSP00000418536
ENST00000485523
Q9NPA1 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0000287 [magnesium ion binding]
GO:0001508 [action potential]
GO:0004427 [inorganic diphosphatase activity]
GO:0005513 [detection of calcium ion]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 257 aa
29 kDa 		No 2
KCNMB3-002
ENSP00000417091
ENST00000497599
Q9NPA1 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001508 [action potential]
GO:0005513 [detection of calcium ion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 173 aa
19.5 kDa 		No 1
KCNMB3-004
ENSP00000319370
ENST00000314235
Q9NPA1 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0001508 [action potential]
GO:0005513 [detection of calcium ion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 279 aa
31.6 kDa 		No 2
KCNMB3-005
ENSP00000376451
ENST00000392685
Q9NPA1 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0000287 [magnesium ion binding]
GO:0001508 [action potential]
GO:0004427 [inorganic diphosphatase activity]
GO:0005513 [detection of calcium ion]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 275 aa
31.1 kDa 		No 2
KCNMB3-006
ENSP00000479162
ENST00000486944
A0A087WV41 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Predicted intracellular proteins
Show all
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
 64 aa
7.4 kDa 		No 0
KCNMB3-007
ENSP00000327866
ENST00000349697
Q9NPA1 [Direct mapping]
Calcium-activated potassium channel subunit beta-3
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0001508 [action potential]
GO:0005513 [detection of calcium ion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 277 aa
31.4 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.