Cell atlas - KCNG3 - The Human Protein Atlas

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KCNG3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytoplasmic bodies

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	KCNG3
Gene description	Potassium channel, voltage gated modifier subfamily G, member 3
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytoplasmic bodies.
RNA cell category	Group enriched (HMC-1, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytoplasmic bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041625
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytoplasmic bodies.

Main location

Cytoplasmic bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041625	HEK 293	Cytoplasmic bodies
	HPA041625	U-2 OS	No staining

GENE INFORMATION
Gene name	KCNG3 (HGNC Symbol)
Synonyms	Kv6.3
Description	Potassium channel, voltage gated modifier subfamily G, member 3 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	42442017 - 42494097
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171126 (version 83.38)
Entrez gene	170850
UniProt	Q8TAE7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAE7
Antibodypedia	KCNG3 antibodies

PROTEIN BROWSER

KCNG3-001	KCNG3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNG3-001 ENSP00000304127 ENST00000306078	Q8TAE7 [Direct mapping] Potassium voltage-gated channel subfamily G member 3 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	436 aa 49.6 kDa	No	7
KCNG3-002 ENSP00000378424 ENST00000394973	Q8TAE7 [Direct mapping] Potassium voltage-gated channel subfamily G member 3 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	425 aa 48.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.