Cell atlas - ATP6V0E2 - The Human Protein Atlas

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ATP6V0E2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ATP6V0E2
Gene description	ATPase, H+ transporting V0 subunit e2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ATP6V0E2 (HGNC Symbol)
Synonyms	ATP6V0E2L, C7orf32
Description	ATPase, H+ transporting V0 subunit e2 (HGNC Symbol)
Entrez gene summary	Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	149872968 - 149880698
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000171130 (version 83.38)
Entrez gene	155066
UniProt	Q8NHE4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NHE4
Antibodypedia	ATP6V0E2 antibodies

PROTEIN BROWSER

ATP6V0E2-001	ATP6V0E2-002	ATP6V0E2-003	ATP6V0E2-007	ATP6V0E2-010	ATP6V0E2-011	ATP6V0E2-201	ATP6V0E2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V0E2-001 ENSP00000411672 ENST00000421974	E9PAS2 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] Show all	213 aa 22 kDa	Yes	2
ATP6V0E2-002 ENSP00000410220 ENST00000456496	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	130 aa 14.3 kDa	Yes	2
ATP6V0E2-003 ENSP00000417939 ENST00000479613	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	187 aa 19.5 kDa	No	2
ATP6V0E2-007 ENSP00000475645 ENST00000464662	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	81 aa 9.2 kDa	No	2
ATP6V0E2-010 ENSP00000396148 ENST00000425642	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	81 aa 9.2 kDa	No	2
ATP6V0E2-011 ENSP00000475904 ENST00000606024	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	164 aa 16.9 kDa	No	2
ATP6V0E2-201 ENSP00000482231 ENST00000611515	E9PAS2 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] Show all	213 aa 22 kDa	Yes	2
ATP6V0E2-202 ENSP00000481176 ENST00000615196	Q8NHE4 [Direct mapping] V-type proton ATPase subunit e 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008152 [metabolic process] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042625 [ATPase activity, coupled to transmembrane movement of ions] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	130 aa 14.3 kDa	Yes	2

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The Human Protein Atlas

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