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GRIK1

GENERAL INFORMATION

Gene name

 GRIK1

Gene description

 Glutamate receptor, ionotropic, kainate 1

Protein class

 FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (hypothalamus, hippocampus)
FANTOM5:Tissue enhanced (retina, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA014623
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 GRIK1 (HGNC Symbol)

Synonyms

 GluK1, GLUR5

Description

 Glutamate receptor, ionotropic, kainate 1 (HGNC Symbol)

Entrez gene summary

 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 29536933 - 29940033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171189 (version 83.38)

Entrez gene

 2897

UniProt

 P39086 (UniProt - Evidence at protein level)

neXtProt

 NX_P39086

Antibodypedia

 GRIK1 antibodies

PROTEIN BROWSER
GRIK1-001
GRIK1-002
GRIK1-003
GRIK1-004
GRIK1-005
GRIK1-006
GRIK1-008
GRIK1-201
GRIK1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRIK1-001
ENSP00000373777
ENST00000389125
P39086 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0015277 [kainate selective glutamate receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
Show all
 905 aa
102.6 kDa 		No 3
GRIK1-002
ENSP00000382791
ENST00000399907
P39086 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0014054 [positive regulation of gamma-aminobutyric acid secretion]
GO:0014069 [postsynaptic density]
GO:0015277 [kainate selective glutamate receptor activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042391 [regulation of membrane potential]
GO:0042734 [presynaptic membrane]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048266 [behavioral response to pain]
GO:0051899 [membrane depolarization]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0060079 [excitatory postsynaptic potential]
GO:0060080 [inhibitory postsynaptic potential]
GO:0097481 [neuronal postsynaptic density]
Show all
 918 aa
104 kDa 		No 3
GRIK1-003
ENSP00000382798
ENST00000399914
E7EPY9 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 934 aa
106.2 kDa 		No 3
GRIK1-004
ENSP00000327687
ENST00000327783
E7ENK3 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 949 aa
107.9 kDa 		No 3
GRIK1-005
ENSP00000373776
ENST00000389124
H7BYG7 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 871 aa
98.8 kDa 		No 3
GRIK1-006
ENSP00000382797
ENST00000399913
E9PD61 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 920 aa
104.4 kDa 		No 3
GRIK1-008
ENSP00000382793
ENST00000399909
E7EPZ0 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 903 aa
102.3 kDa 		No 3
GRIK1-201
ENSP00000311646
ENST00000309434
F8W7X3 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 879 aa
99.5 kDa 		No 3
GRIK1-202
ENSP00000446326
ENST00000535441
F5H1W5 [Direct mapping]
Glutamate receptor ionotropic, kainate 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042734 [presynaptic membrane]
GO:0045211 [postsynaptic membrane]
Show all
 866 aa
98.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.