Cell atlas - SCAND1 - The Human Protein Atlas

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SCAND1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Nucleus

Human cell
	Actin Filaments
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SCAND1
Gene description	SCAN domain containing 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol & actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Actin filaments (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047138
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol & actin filaments.

Main location

Nucleus (approved)

Additional location

Actin filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047138	HEK 293	Nucleus
	HPA047138	HEK 293	Cytosol
	HPA047138	PC-3	Nucleoplasm
	HPA047138	PC-3	Cytosol
	HPA047138	U-2 OS	Nucleoplasm
			Actin filaments
			Cytosol

GENE INFORMATION
Gene name	SCAND1 (HGNC Symbol)
Synonyms	RAZ1, SDP1
Description	SCAN domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	35953617 - 35959472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171222 (version 83.38)
Entrez gene	51282
UniProt	P57086 (UniProt - Evidence at protein level)
neXtProt	NX_P57086
Antibodypedia	SCAND1 antibodies

PROTEIN BROWSER

SCAND1-001	SCAND1-002	SCAND1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCAND1-001 ENSP00000363103 ENST00000373991	P57086 [Direct mapping] SCAN domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0042802 [identical protein binding] Show all	179 aa 19.1 kDa	No	0
SCAND1-002 ENSP00000301995 ENST00000305978	P57086 [Direct mapping] SCAN domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0042802 [identical protein binding] Show all	179 aa 19.1 kDa	No	0
SCAND1-201 ENSP00000481289 ENST00000615116	P57086 [Direct mapping] SCAN domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0042802 [identical protein binding] Show all	179 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.