Cell atlas - TMEM37 - The Human Protein Atlas

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TMEM37

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli fibrillar center
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TMEM37
Gene description	Transmembrane protein 37
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus & cytosol.
RNA cell category	Cell line enhanced (Hep G2, RPTEC TERT1, EFO-21)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoli fibrillar center (approved)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053794
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, RPTEC TERT1, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus & cytosol.

Main location

Nucleoli fibrillar center (approved)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053794	CACO-2	Nucleoli fibrillar center
	HPA053794	Hep G2	Nucleus
			Nucleoli fibrillar center
			Cytosol
	HPA053794	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	TMEM37 (HGNC Symbol)
Synonyms	PR, PR1
Description	Transmembrane protein 37 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q14.2
Chromosome location (bp)	119429901 - 119438520
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000171227 (version 83.38)
Entrez gene	140738
UniProt	Q8WXS4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WXS4
Antibodypedia	TMEM37 antibodies

PROTEIN BROWSER

TMEM37-001	TMEM37-003	TMEM37-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM37-001 ENSP00000303148 ENST00000306406	Q8WXS4 [Direct mapping] Voltage-dependent calcium channel gamma-like subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005262 [calcium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	190 aa 20.9 kDa	No	4
TMEM37-003 ENSP00000400770 ENST00000417645	C9J1Q8 [Direct mapping] Voltage-dependent calcium channel gamma-like subunit Show all	Predicted intracellular proteins Show all		67 aa 7.1 kDa	No	0
TMEM37-004 ENSP00000387015 ENST00000409826	E7EMC0 [Direct mapping] Voltage-dependent calcium channel gamma-like subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005262 [calcium channel activity] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	202 aa 22.4 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.