Expression of UGT2B7 in cancer - Summary

CANCER ATLAS

Gene description

UDP glucuronosyltransferase 2 family, polypeptide B7

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045108

GENE INFORMATION
Gene name	UGT2B7 (HGNC Symbol)
Synonyms	UGT2B9
Description	UDP glucuronosyltransferase 2 family, polypeptide B7 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]
Chromosome	4
Cytoband	q13.2
Chromosome location (bp)	69051363 - 69112987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171234 (version 83.38)
Entrez gene	7364
UniProt	P16662 (UniProt - Evidence at protein level)
neXtProt	NX_P16662
Antibodypedia	UGT2B7 antibodies

PROTEIN BROWSER

UGT2B7-001	UGT2B7-002	UGT2B7-003	UGT2B7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT2B7-001 ENSP00000304811 ENST00000305231	P16662 [Direct mapping] UDP-glucuronosyltransferase 2B7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0008209 [androgen metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052695 [cellular glucuronidation] GO:0052696 [flavonoid glucuronidation] GO:0070062 [extracellular exosome] Show all	529 aa 60.7 kDa	Yes	1
UGT2B7-002 ENSP00000427659 ENST00000508661	E9PBP8 [Direct mapping] UDP-glucuronosyltransferase 2B7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	369 aa 42.7 kDa	Yes	0
UGT2B7-003 ENSP00000426206 ENST00000502942	D6RH08 [Direct mapping] UDP-glucuronosyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	156 aa 17.3 kDa	No	0
UGT2B7-201 ENSP00000483172 ENST00000622664	A0A087X084 [Direct mapping] UDP-glucuronosyltransferase 2B7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	335 aa 38.5 kDa	Yes	0