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CHST11

GENERAL INFORMATION

Gene name

 CHST11

Gene description

 Carbohydrate (chondroitin 4) sulfotransferase 11

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA052828
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHST11 (HGNC Symbol)

Synonyms

 C4ST, C4St-1, C4ST1, HSA269537

Description

 Carbohydrate (chondroitin 4) sulfotransferase 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 104455295 - 104762014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171310 (version 83.38)

Entrez gene

 50515

UniProt

 Q9NPF2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPF2

Antibodypedia

 CHST11 antibodies

PROTEIN BROWSER
CHST11-001
CHST11-002
CHST11-005
CHST11-006
CHST11-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHST11-001
ENSP00000305725
ENST00000303694
Q9NPF2 [Direct mapping]
Carbohydrate sulfotransferase 11
A0A024RBL0 [Target identity:100%; Query identity:100%]
Carbohydrate (Chondroitin 4) sulfotransferase 11, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity]
GO:0002063 [chondrocyte development]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008146 [sulfotransferase activity]
GO:0009791 [post-embryonic development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016051 [carbohydrate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030326 [embryonic limb morphogenesis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0033037 [polysaccharide localization]
GO:0036342 [post-anal tail morphogenesis]
GO:0042127 [regulation of cell proliferation]
GO:0042733 [embryonic digit morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0047756 [chondroitin 4-sulfotransferase activity]
GO:0048589 [developmental growth]
GO:0048703 [embryonic viscerocranium morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050659 [N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity]
GO:0051216 [cartilage development]
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 352 aa
41.6 kDa 		Yes 0
CHST11-002
ENSP00000450004
ENST00000549260
Q9NPF2 [Direct mapping]
Carbohydrate sulfotransferase 11
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001537 [N-acetylgalactosamine 4-O-sulfotransferase activity]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0008146 [sulfotransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016051 [carbohydrate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0047756 [chondroitin 4-sulfotransferase activity]
Show all
 347 aa
41 kDa 		No 0
CHST11-005
ENSP00000449095
ENST00000549016
F8VXK3 [Direct mapping]
Carbohydrate sulfotransferase 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0016051 [carbohydrate biosynthetic process]
Show all
 158 aa
18.5 kDa 		No 0
CHST11-006
ENSP00000448678
ENST00000546689
F8VRG6 [Direct mapping]
Carbohydrate sulfotransferase 11
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0016051 [carbohydrate biosynthetic process]
Show all
 72 aa
8.4 kDa 		No 0
CHST11-007
ENSP00000449093
ENST00000547956
F8VXK7 [Direct mapping]
Carbohydrate sulfotransferase 11
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0016051 [carbohydrate biosynthetic process]
Show all
 77 aa
8.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.