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Most renal cell carcinomas, testicular cancers along with a few melanomas, endometrial, breast, ovarian, urothelial, head and neck cancers showed moderate cytoplasmic positivity. Other cancer tissues were weakly stained or negative.
Most cancer tissues exhibited weak to moderate cytoplasmic and nuclear immunoreactivity. Additional membranous staining was observed in colorectal cancers. Follicular adenocarcinoma of thyroid and a few renal cancers were strongly stained. Several lung and prostate cancers were negative.
GENE INFORMATION
Gene name
PGAM1 (HGNC Symbol)
Synonyms
PGAM-B, PGAMA
Description
Phosphoglycerate mutase 1 (brain) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
P18669 [Direct mapping] Phosphoglycerate mutase 1 Q6FHU2 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 35; HCG2015269, isoform CRA_a; PGAM1 protein; Phosphoglycerate mutase 1 (Brain); Phosphoglycerate mutase 1 (Brain), isoform CRA_b; cDNA FLJ77692, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA FLJ78401, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA, FLJ92670, Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA
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Enzymes ENZYME proteins Hydrolases Isomerase Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
