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APLN

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GENERAL INFORMATION

Gene name

 APLN

Gene description

 Apelin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HUVEC TERT2)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HUVEC TERT2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 APLN (HGNC Symbol)

Synonyms

 apelin, XNPEP2

Description

 Apelin (HGNC Symbol)

Entrez gene summary

 This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]

Chromosome

 X

Cytoband

 q26.1

Chromosome location (bp)

 129645259 - 129654937

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000171388 (version 83.38)

Entrez gene

 8862

UniProt

 Q9ULZ1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9ULZ1

Antibodypedia

 APLN antibodies

PROTEIN BROWSER
APLN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APLN-001
ENSP00000391800
ENST00000429967
Q9ULZ1 [Direct mapping]
Apelin Apelin-36 Apelin-31 Apelin-28 Apelin-13
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002026 [regulation of the force of heart contraction]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007595 [lactation]
GO:0007631 [feeding behavior]
GO:0008284 [positive regulation of cell proliferation]
GO:0031652 [positive regulation of heat generation]
GO:0031704 [apelin receptor binding]
GO:0042327 [positive regulation of phosphorylation]
GO:0042756 [drinking behavior]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045776 [negative regulation of blood pressure]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050878 [regulation of body fluid levels]
GO:0051461 [positive regulation of corticotropin secretion]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
Show all
 77 aa
8.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.