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CDK5R2

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GENERAL INFORMATION

Gene name

 CDK5R2

Gene description

 Cyclin-dependent kinase 5, regulatory subunit 2 (p39)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (SCLC-21H, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CDK5R2 (HGNC Symbol)

Synonyms

 NCK5AI, P39, p39nck5ai

Description

 Cyclin-dependent kinase 5, regulatory subunit 2 (p39) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218959655 - 218962162

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171450 (version 83.38)

Entrez gene

 8941

UniProt

 Q13319 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13319

Antibodypedia

 CDK5R2 antibodies

PROTEIN BROWSER
CDK5R2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK5R2-001
ENSP00000304250
ENST00000302625
Q13319 [Direct mapping]
Cyclin-dependent kinase 5 activator 2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0001764 [neuron migration]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008289 [lipid binding]
GO:0016533 [cyclin-dependent protein kinase 5 holoenzyme complex]
GO:0016534 [cyclin-dependent protein kinase 5 activator activity]
GO:0021549 [cerebellum development]
GO:0021722 [superior olivary nucleus maturation]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 367 aa
38.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.