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A few squamous cell carcinomas and one case of endometrial cancer showed strong cytoplasmic positivity. A few skin and prostate cancers showed weak to moderate cytoplasmic positivity. Other cancers were generally negative.
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding]