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Subset of cells in few cases of breast, thyroid, testis, urothelial and renal cancer displayed granular weak cytoplasmic positivity while in a single case of pancreatic cancers exhibited moderate staining. Remaining cancer tissues were negative.
Few cases of gliomas, carcinoids, urothelial and thyroid cancers along with Hodgkin's lymphomas displayed weak to moderate nuclear and cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
HOPX (HGNC Symbol)
Synonyms
HOP, LAGY, NECC1, OB1, SMAP31
Description
HOP homeobox (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001829 [trophectodermal cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0045596 [negative regulation of cell differentiation]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001829 [trophectodermal cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0045596 [negative regulation of cell differentiation]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001829 [trophectodermal cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0045596 [negative regulation of cell differentiation]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001829 [trophectodermal cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0045596 [negative regulation of cell differentiation]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001829 [trophectodermal cell differentiation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007507 [heart development] GO:0008016 [regulation of heart contraction] GO:0016575 [histone deacetylation] GO:0043393 [regulation of protein binding] GO:0043415 [positive regulation of skeletal muscle tissue regeneration] GO:0045596 [negative regulation of cell differentiation] GO:0048286 [lung alveolus development] GO:0051155 [positive regulation of striated muscle cell differentiation]
