Expression of LPAR3 in cancer - Summary

CANCER ATLAS

Gene description

Lysophosphatidic acid receptor 3

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013421

GENE INFORMATION
Gene name	LPAR3 (HGNC Symbol)
Synonyms	Edg-7, EDG7, HOFNH30, LP-A3, LPA3, RP4-678I3
Description	Lysophosphatidic acid receptor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	84811602 - 84893213
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171517 (version 83.38)
Entrez gene	23566
UniProt	Q9UBY5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UBY5
Antibodypedia	LPAR3 antibodies

PROTEIN BROWSER

LPAR3-001	LPAR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR3-001 ENSP00000395389 ENST00000440886	Q9UBY5 [Direct mapping] Lysophosphatidic acid receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0000187 [activation of MAPK activity] GO:0001965 [G-protein alpha-subunit binding] GO:0004930 [G-protein coupled receptor activity] GO:0005543 [phospholipid binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0032060 [bleb assembly] GO:0043410 [positive regulation of MAPK cascade] GO:0048672 [positive regulation of collateral sprouting] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0051928 [positive regulation of calcium ion transport] GO:0070915 [lysophosphatidic acid receptor activity] Show all	353 aa 40.1 kDa	No	7
LPAR3-201 ENSP00000359643 ENST00000370611	Q9UBY5 [Direct mapping] Lysophosphatidic acid receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0070915 [lysophosphatidic acid receptor activity] Show all	353 aa 40.1 kDa	No	7