Cell atlas - ECEL1 - The Human Protein Atlas

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ECEL1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoli
	Nucleoplasm

Human cell
	Nuclear membrane
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ECEL1
Gene description	Endothelin converting enzyme-like 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the nucleoli.
RNA cell category	Group enriched (AN3-CA, HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear membrane (approved)
Additional location	In addition localized to the Nucleoli (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA067560
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (AN3-CA, HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the nucleoli.

Main location

Nucleoplasm (approved), Nuclear membrane (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067560	HeLa	Nucleoplasm
	HPA067560	HeLa	Nucleoli	Intensity
	HPA067560	SH-SY5Y	Nucleoplasm
	HPA067560	SH-SY5Y	Nuclear membrane
	HPA067560	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ECEL1 (HGNC Symbol)
Synonyms	DINE, XCE
Description	Endothelin converting enzyme-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	232479827 - 232487828
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171551 (version 83.38)
Entrez gene	9427
UniProt	O95672 (UniProt - Evidence at protein level)
neXtProt	NX_O95672
Antibodypedia	ECEL1 antibodies

PROTEIN BROWSER

ECEL1-001	ECEL1-003	ECEL1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECEL1-001 ENSP00000302051 ENST00000304546	O95672 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003016 [respiratory system process] GO:0004222 [metalloendopeptidase activity] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007218 [neuropeptide signaling pathway] GO:0008237 [metallopeptidase activity] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	775 aa 87.8 kDa	No	1
ECEL1-003 ENSP00000386333 ENST00000409941	O95672 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003016 [respiratory system process] GO:0004222 [metalloendopeptidase activity] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0046872 [metal ion binding] Show all	773 aa 87.6 kDa	No	1
ECEL1-005 ENSP00000412683 ENST00000411860	H7C3M0 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007218 [neuropeptide signaling pathway] Show all	168 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.