Cell atlas - PLRG1 - The Human Protein Atlas

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PLRG1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nuclear speckles

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PLRG1
Gene description	Pleiotropic regulator 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (validated)
Additional location	In addition localized to the Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035931 , HPA061486
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the nuclear membrane.

Main location

Nuclear speckles (validated)

Additional location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035931	A-431	Nuclear speckles
	HPA035931	U-2 OS	Nuclear speckles
	HPA035931	U-251 MG	Nuclear speckles
	HPA061486	Hep G2	Nuclear membrane
	HPA061486	Hep G2	Nuclear speckles
	HPA061486	MCF7	Nuclear membrane
			Nucleoli fibrillar center
			Nuclear speckles
	HPA061486	U-2 OS	Nuclear membrane
	HPA061486	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	PLRG1 (HGNC Symbol)
Synonyms	Cwc1, PRL1, Prp46, PRPF46, TANGO4
Description	Pleiotropic regulator 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	4
Cytoband	q31.3
Chromosome location (bp)	154535006 - 154550435
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171566 (version 83.38)
Entrez gene	5356
UniProt	O43660 (UniProt - Evidence at protein level)
neXtProt	NX_O43660
Antibodypedia	PLRG1 antibodies

PROTEIN BROWSER

PLRG1-001	PLRG1-003	PLRG1-006	PLRG1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLRG1-001 ENSP00000424417 ENST00000499023	O43660 [Direct mapping] Pleiotropic regulator 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0000974 [Prp19 complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005662 [DNA replication factor A complex] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016607 [nuclear speck] GO:0034504 [protein localization to nucleus] GO:0071011 [precatalytic spliceosome] GO:0071013 [catalytic step 2 spliceosome] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] Show all	514 aa 57.2 kDa	No	0
PLRG1-003 ENSP00000303191 ENST00000302078	O43660 [Direct mapping] Pleiotropic regulator 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0000974 [Prp19 complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005662 [DNA replication factor A complex] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016607 [nuclear speck] GO:0071011 [precatalytic spliceosome] GO:0071013 [catalytic step 2 spliceosome] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	505 aa 56.3 kDa	No	0
PLRG1-006 ENSP00000423454 ENST00000504341	D6RA26 [Direct mapping] Pleiotropic regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	212 aa 23.5 kDa	No	0
PLRG1-012 ENSP00000426497 ENST00000503251	H0YAA2 [Direct mapping] Pleiotropic regulator 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	106 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.