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A majority of cases in malignant gliomas, malignant carcinoids and testis cancers displayed showed moderate to strong cytoplasmic staining. Most of the remaining malignant cells were negative.
GENE INFORMATION
Gene name
DSCAM (HGNC Symbol)
Synonyms
CHD2-42, CHD2-52
Description
Down syndrome cell adhesion molecule (HGNC Symbol)
Entrez gene summary
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]