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ZNF274

GENERAL INFORMATION

Gene name

 ZNF274

Gene description

 Zinc finger protein 274

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA028880
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZNF274 (HGNC Symbol)

Synonyms

 ZKSCAN19, ZSCAN51

Description

 Zinc finger protein 274 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 58183029 - 58213562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171606 (version 83.38)

Entrez gene

 10782

UniProt

 Q96GC6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GC6

Antibodypedia

 ZNF274 antibodies

PROTEIN BROWSER
ZNF274-001
ZNF274-008
ZNF274-009
ZNF274-010
ZNF274-011
ZNF274-014
ZNF274-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF274-001
ENSP00000409872
ENST00000424679
Q96GC6 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 548 aa
62.1 kDa 		No 0
ZNF274-008
ENSP00000469546
ENST00000597528
M0QY30 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 79 aa
9.2 kDa 		No 0
ZNF274-009
ENSP00000478533
ENST00000610905
Q96GC6 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 653 aa
74.2 kDa 		No 0
ZNF274-010
ENSP00000321187
ENST00000345813
Q96GC6 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 621 aa
70.5 kDa 		No 0
ZNF274-011
ENSP00000469427
ENST00000594839
M0QXW4 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 103 aa
11.8 kDa 		No 0
ZNF274-014
ENSP00000484810
ENST00000617501
Q96GC6 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 653 aa
74.2 kDa 		No 0
ZNF274-015
ENSP00000321209
ENST00000326804
A0A0A0MR47 [Direct mapping]
Neurotrophin receptor-interacting factor homolog
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 611 aa
69.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.