Fields »
ABOUT
HELP
BLOG
PIK3CD

GENERAL INFORMATION

Gene name

 PIK3CD

Gene description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA044953 , CAB015420
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PIK3CD (HGNC Symbol)

Synonyms

 p110D

Description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (HGNC Symbol)

Entrez gene summary

 Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9651732 - 9729114

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171608 (version 83.38)

Entrez gene

 5293

UniProt

 O00329 (UniProt - Evidence at protein level)

neXtProt

 NX_O00329

Antibodypedia

 PIK3CD antibodies

PROTEIN BROWSER
PIK3CD-001
PIK3CD-003
PIK3CD-201
PIK3CD-202
PIK3CD-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3CD-001
ENSP00000366563
ENST00000377346
O00329 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001779 [natural killer cell differentiation]
GO:0001782 [B cell homeostasis]
GO:0001816 [cytokine production]
GO:0002250 [adaptive immune response]
GO:0002551 [mast cell chemotaxis]
GO:0002679 [respiratory burst involved in defense response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010818 [T cell chemotaxis]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030101 [natural killer cell activation]
GO:0030168 [platelet activation]
GO:0030217 [T cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035747 [natural killer cell chemotaxis]
GO:0035754 [B cell chemotaxis]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048872 [homeostasis of number of cells]
GO:0050832 [defense response to fungus]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0060374 [mast cell differentiation]
GO:0072672 [neutrophil extravasation]
Show all
 1044 aa
119.5 kDa 		No 0
PIK3CD-003
ENSP00000354410
ENST00000361110
F8W9P4 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 1068 aa
122 kDa 		No 0
PIK3CD-201
ENSP00000446444
ENST00000536656
Q5SR50 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 1068 aa
121.8 kDa 		No 0
PIK3CD-202
ENSP00000443811
ENST00000543390
Q5SR50 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 1068 aa
121.8 kDa 		No 0
PIK3CD-203
ENSP00000486826
ENST00000628140
F8W9P4 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 1068 aa
122 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.