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ENC1

GENERAL INFORMATION

Gene name

 ENC1

Gene description

 Ectodermal-neural cortex 1 (with BTB domain)

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, hippocampus)
FANTOM5:Group enriched (brain, hippocampus, caudate)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, caudate)

GENE INFORMATION

Gene name

 ENC1 (HGNC Symbol)

Synonyms

 ENC-1, KLHL37, NRPB, PIG10, TP53I10

Description

 Ectodermal-neural cortex 1 (with BTB domain) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 74627406 - 74641424

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171617 (version 83.38)

Entrez gene

 8507

UniProt

 O14682 (UniProt - Evidence at protein level)

neXtProt

 NX_O14682

Antibodypedia

 ENC1 antibodies

PROTEIN BROWSER
ENC1-001
ENC1-002
ENC1-004
ENC1-005
ENC1-201
ENC1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENC1-001
ENSP00000306356
ENST00000302351
O14682 [Direct mapping]
Ectoderm-neural cortex protein 1
Q53XS2 [Target identity:100%; Query identity:100%]
Ectodermal-neural cortex (With BTB-like domain); cDNA FLJ39259 fis, clone OCBBF2009301, highly similar to Ectoderm-neural cortex 1 protein; cDNA, FLJ92986, Homo sapiens ectodermal-neural cortex (with BTB-like domain)(ENC1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0007275 [multicellular organismal development]
GO:0007399 [nervous system development]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0016363 [nuclear matrix]
GO:0016567 [protein ubiquitination]
GO:0017148 [negative regulation of translation]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 589 aa
66.1 kDa 		No 0
ENC1-002
ENSP00000423804
ENST00000510316
O14682 [Direct mapping]
Ectoderm-neural cortex protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0007275 [multicellular organismal development]
GO:0007399 [nervous system development]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0016363 [nuclear matrix]
GO:0016567 [protein ubiquitination]
GO:0017148 [negative regulation of translation]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 516 aa
57.9 kDa 		No 0
ENC1-004
ENSP00000426889
ENST00000509127
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 4 aa
0.4 kDa 		No 0
ENC1-005
ENSP00000422943
ENST00000508331
D6R9D7 [Direct mapping]
Ectoderm-neural cortex protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007399 [nervous system development]
Show all
 50 aa
5.7 kDa 		No 0
ENC1-201
ENSP00000446289
ENST00000537006
O14682 [Direct mapping]
Ectoderm-neural cortex protein 1
Q53XS2 [Target identity:100%; Query identity:100%]
Ectodermal-neural cortex (With BTB-like domain); cDNA FLJ39259 fis, clone OCBBF2009301, highly similar to Ectoderm-neural cortex 1 protein; cDNA, FLJ92986, Homo sapiens ectodermal-neural cortex (with BTB-like domain)(ENC1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0007275 [multicellular organismal development]
GO:0007399 [nervous system development]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0016363 [nuclear matrix]
GO:0016567 [protein ubiquitination]
GO:0017148 [negative regulation of translation]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
Show all
 589 aa
66.1 kDa 		No 0
ENC1-202
ENSP00000479101
ENST00000618628
O14682 [Direct mapping]
Ectoderm-neural cortex protein 1
Q53XS2 [Target identity:100%; Query identity:100%]
Ectodermal-neural cortex (With BTB-like domain); cDNA FLJ39259 fis, clone OCBBF2009301, highly similar to Ectoderm-neural cortex 1 protein; cDNA, FLJ92986, Homo sapiens ectodermal-neural cortex (with BTB-like domain)(ENC1), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0007275 [multicellular organismal development]
GO:0007399 [nervous system development]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010976 [positive regulation of neuron projection development]
GO:0016363 [nuclear matrix]
GO:0016567 [protein ubiquitination]
GO:0017148 [negative regulation of translation]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0043025 [neuronal cell body]
Show all
 589 aa
66.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.