Tissue expression of P2RY6 - Summary - The Human Protein Atlas

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P2RY6

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	P2RY6
Gene description	Pyrimidinergic receptor P2Y, G-protein coupled, 6
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen, placenta)
GTEx:	Tissue enriched (spleen)
FANTOM5:	Tissue enhanced (placenta, spleen)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB022740
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta, spleen)

GENE INFORMATION
Gene name	P2RY6 (HGNC Symbol)
Synonyms	P2Y6
Description	Pyrimidinergic receptor P2Y, G-protein coupled, 6 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	73264505 - 73298617
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171631 (version 83.38)
Entrez gene	5031
UniProt	Q15077 (UniProt - Evidence at protein level)
neXtProt	NX_Q15077
Antibodypedia	P2RY6 antibodies

PROTEIN BROWSER

P2RY6-001	P2RY6-002	P2RY6-003	P2RY6-004	P2RY6-005	P2RY6-006	P2RY6-007	P2RY6-008	P2RY6-009	P2RY6-010	P2RY6-011	P2RY6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P2RY6-001 ENSP00000443427 ENST00000540342	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-002 ENSP00000445652 ENST00000542092	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-003 ENSP00000309771 ENST00000349767	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-004 ENSP00000377217 ENST00000393592	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-005 ENSP00000377216 ENST00000393591	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-006 ENSP00000442551 ENST00000540124	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-007 ENSP00000377215 ENST00000393590	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-008 ENSP00000442990 ENST00000538328	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	328 aa 36.4 kDa	No	7
P2RY6-009 ENSP00000441079 ENST00000544437	F5GX90 [Direct mapping] P2Y purinoceptor 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	128 aa 14.3 kDa	No	3
P2RY6-010 ENSP00000442509 ENST00000536225	F5H7H9 [Direct mapping] P2Y purinoceptor 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	56 aa 6.2 kDa	No	1
P2RY6-011 ENSP00000440770 ENST00000535931	F5GYF3 [Direct mapping] P2Y purinoceptor 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	245 aa 27 kDa	No	5
P2RY6-201 ENSP00000480966 ENST00000618468	Q15077 [Direct mapping] P2Y purinoceptor 6 A0A024R5I9 [Target identity:100%; Query identity:100%] Pyrimidinergic receptor P2Y, G-protein coupled, 6, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030321 [transepithelial chloride transport] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] GO:0045029 [UDP-activated nucleotide receptor activity] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071407 [cellular response to organic cyclic compound] Show all	328 aa 36.4 kDa	No	7

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The Human Protein Atlas

The Human Protein Atlas project is funded
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