Cell atlas - TCEA2 - The Human Protein Atlas

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TCEA2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TCEA2
Gene description	Transcription elongation factor A (SII), 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Centrosome (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA043836
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome & nucleoplasm.

Main location

Nucleoplasm (supported), Centrosome (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043836	A-431	Nucleoplasm
	HPA043836	A-431	Centrosome
	HPA043836	U-2 OS	Nucleoplasm
	HPA043836	U-2 OS	Centrosome
	HPA043836	U-251 MG	Nucleoplasm
	HPA043836	U-251 MG	Centrosome

GENE INFORMATION
Gene name	TCEA2 (HGNC Symbol)
Synonyms	TFIIS
Description	Transcription elongation factor A (SII), 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	64049836 - 64072347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171703 (version 83.38)
Entrez gene	6919
UniProt	Q15560 (UniProt - Evidence at protein level)
neXtProt	NX_Q15560
Antibodypedia	TCEA2 antibodies

PROTEIN BROWSER

TCEA2-001	TCEA2-002	TCEA2-003	TCEA2-004	TCEA2-008	TCEA2-009	TCEA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCEA2-001 ENSP00000343515 ENST00000343484	Q15560 [Direct mapping] Transcription elongation factor A protein 2 Q6IB64 [Target identity:100%; Query identity:100%] TCEA2 protein; Transcription elongation factor A (SII), 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006354 [DNA-templated transcription, elongation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008023 [transcription elongation factor complex] GO:0008270 [zinc ion binding] GO:0032784 [regulation of DNA-templated transcription, elongation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	299 aa 33.6 kDa	No	0
TCEA2-002 ENSP00000416026 ENST00000458442	A0A0A0MT58 [Direct mapping] Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0032784 [regulation of DNA-templated transcription, elongation] Show all	270 aa 30.3 kDa	No	0
TCEA2-003 ENSP00000339432 ENST00000339217	Q5JRI7 [Direct mapping] Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0032784 [regulation of DNA-templated transcription, elongation] Show all	246 aa 27.5 kDa	No	0
TCEA2-004 ENSP00000407085 ENST00000440819	Q5JRI7 [Direct mapping] Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0032784 [regulation of DNA-templated transcription, elongation] Show all	246 aa 27.5 kDa	No	0
TCEA2-008 ENSP00000354552 ENST00000361317	Q15560 [Direct mapping] Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006354 [DNA-templated transcription, elongation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008023 [transcription elongation factor complex] GO:0008270 [zinc ion binding] GO:0032784 [regulation of DNA-templated transcription, elongation] Show all	272 aa 30.6 kDa	No	0
TCEA2-009 ENSP00000391807 ENST00000415602	Q5JRI8 [Direct mapping] Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	82 aa 9 kDa	No	0
TCEA2-201 ENSP00000378493 ENST00000395053	Q86VL0 [Direct mapping] TCEA2 protein; Transcription elongation factor A (SII), 2, isoform CRA_b; Transcription elongation factor A protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003746 [translation elongation factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006414 [translational elongation] GO:0032784 [regulation of DNA-templated transcription, elongation] Show all	242 aa 26.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.