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DEFB4A

GENERAL INFORMATION

Gene name

 DEFB4A

Gene description

 Defensin, beta 4A

Protein class

 Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (tonsil, gallbladder, esophagus)
GTEx:Group enriched (esophagus, salivary gland)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, gallbladder, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 DEFB4A (HGNC Symbol)

Synonyms

 DEFB-2, DEFB102, DEFB2, DEFB4, HBD-2, SAP1

Description

 Defensin, beta 4A (HGNC Symbol)

Entrez gene summary

 Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 7894629 - 7896711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171711 (version 83.38)

Entrez gene

 1673

UniProt

 O15263 (UniProt - Evidence at protein level)

neXtProt

 NX_O15263

Antibodypedia

 DEFB4A antibodies

PROTEIN BROWSER
DEFB4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFB4A-001
ENSP00000303532
ENST00000302247
O15263 [Direct mapping]
Beta-defensin 4A
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0005796 [Golgi lumen]
GO:0006935 [chemotaxis]
GO:0006952 [defense response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
Show all
 64 aa
7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.