Expression of ANO5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Anoctamin 5

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA058857

GENE INFORMATION
Gene name	ANO5 (HGNC Symbol)
Synonyms	GDD1, LGMD2L, TMEM16E
Description	Anoctamin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Chromosome	11
Cytoband	p14.3
Chromosome location (bp)	22193176 - 22283357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171714 (version 83.38)
Entrez gene	203859
UniProt	Q75V66 (UniProt - Evidence at protein level)
neXtProt	NX_Q75V66
Antibodypedia	ANO5 antibodies

PROTEIN BROWSER

ANO5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANO5-001 ENSP00000315371 ENST00000324559	Q75V66 [Direct mapping] Anoctamin-5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006821 [chloride transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	913 aa 107.2 kDa	No	9