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Most cancers exhibited moderate nuclear and occasional cytoplasmic positivity. Few urothelial along with rare colorectal, breast, ovarian, testis, renal and melanoma cancers showed strong positivity. Several cases of stomach, pancreatic and cervical cancers showed strong cytoplasmic/membranous and nuclear positivity.
A majority of cancer cells were negative or showed weak nuclear staining. Some urothelial cancers, colorectal cancers and renal cancers showed moderate to strong staining.
GENE INFORMATION
Gene name
HDAC3 (HGNC Symbol)
Synonyms
HD3, RPD3, RPD3-2
Description
Histone deacetylase 3 (HGNC Symbol)
Entrez gene summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007219 [Notch signaling pathway] GO:0007346 [regulation of mitotic cell cycle] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0019899 [enzyme binding] GO:0030332 [cyclin binding] GO:0031490 [chromatin DNA binding] GO:0031647 [regulation of protein stability] GO:0032008 [positive regulation of TOR signaling] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0032922 [circadian regulation of gene expression] GO:0033558 [protein deacetylase activity] GO:0040014 [regulation of multicellular organism growth] GO:0042826 [histone deacetylase binding] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045786 [negative regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046329 [negative regulation of JNK cascade] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051225 [spindle assembly] GO:0070932 [histone H3 deacetylation] GO:0071498 [cellular response to fluid shear stress] GO:1903507 [negative regulation of nucleic acid-templated transcription] GO:2000726 [negative regulation of cardiac muscle cell differentiation]
