Cell atlas - COL8A2 - The Human Protein Atlas

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COL8A2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	COL8A2
Gene description	Collagen, type VIII, alpha 2
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (BJ, THP-1, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA049788
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, THP-1, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus.

Main location

Golgi apparatus (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049788	BJ	Golgi apparatus
	HPA049788	SH-SY5Y	Golgi apparatus
	HPA049788	SH-SY5Y	Cytosol
	HPA049788	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	COL8A2 (HGNC Symbol)
Synonyms	FECD, FECD1, PPCD, PPCD2
Description	Collagen, type VIII, alpha 2 (HGNC Symbol)
Entrez gene summary	This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	36095236 - 36125220
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171812 (version 83.38)
Entrez gene	1296
UniProt	P25067 (UniProt - Evidence at protein level)
neXtProt	NX_P25067
Antibodypedia	COL8A2 antibodies

PROTEIN BROWSER

COL8A2-001	COL8A2-002	COL8A2-201	COL8A2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL8A2-001 ENSP00000380901 ENST00000397799	P25067 [Direct mapping] Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0016337 [single organismal cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0030674 [protein binding, bridging] GO:0031012 [extracellular matrix] GO:0048593 [camera-type eye morphogenesis] GO:0050673 [epithelial cell proliferation] Show all	703 aa 67.2 kDa	Yes	0
COL8A2-002 ENSP00000436433 ENST00000481785	E9PP49 [Direct mapping] Collagen alpha-2(VIII) chain; Collagen type VIII alpha 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	638 aa 60.7 kDa	No	0
COL8A2-201 ENSP00000305913 ENST00000303143	P25067 [Direct mapping] Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001525 [angiogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0016337 [single organismal cell-cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0030674 [protein binding, bridging] GO:0031012 [extracellular matrix] Show all	703 aa 67.2 kDa	Yes	0
COL8A2-202 ENSP00000484406 ENST00000615990	Q4VAQ0 [Direct mapping] COL8A2 protein; Collagen alpha-2(VIII) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	427 aa 42.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.