Expression of FBXL14 in cancer - Summary

CANCER ATLAS

Gene description

F-box and leucine-rich repeat protein 14

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053889

GENE INFORMATION
Gene name	FBXL14 (HGNC Symbol)
Synonyms	Fbl14, MGC40195
Description	F-box and leucine-rich repeat protein 14 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	1565993 - 1594165
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171823 (version 83.38)
Entrez gene	144699
UniProt	Q8N1E6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N1E6
Antibodypedia	FBXL14 antibodies

PROTEIN BROWSER

FBXL14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL14-001 ENSP00000344855 ENST00000339235	Q8N1E6 [Direct mapping] F-box/LRR-repeat protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	418 aa 45.9 kDa	No	0