Cell atlas - MLLT3 - The Human Protein Atlas

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MLLT3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MLLT3
Gene description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001824
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001824	U-2 OS	Nucleoplasm
	HPA001824	U-2 OS	Cytosol
	HPA001824	U-251 MG	Nucleoplasm
	HPA001824	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MLLT3 (HGNC Symbol)
Synonyms	AF-9, AF9, YEATS3
Description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	20341665 - 20622543
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171843 (version 83.38)
Entrez gene	4300
UniProt	P42568 (UniProt - Evidence at protein level)
neXtProt	NX_P42568
Antibodypedia	MLLT3 antibodies

PROTEIN BROWSER

MLLT3-001	MLLT3-002	MLLT3-009	MLLT3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLLT3-001 ENSP00000369695 ENST00000380338	P42568 [Direct mapping] Protein AF-9 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007379 [segment specification] GO:0008023 [transcription elongation factor complex] GO:0009952 [anterior/posterior pattern specification] GO:0070062 [extracellular exosome] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway] Show all	568 aa 63.4 kDa	No	0
MLLT3-002 ENSP00000369678 ENST00000380321	B1APT5 [Direct mapping] Protein AF-9 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	162 aa 18.4 kDa	No	0
MLLT3-009 ENSP00000485996 ENST00000630269	P42568 [Direct mapping] Protein AF-9 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008023 [transcription elongation factor complex] GO:0070062 [extracellular exosome] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway] Show all	565 aa 63.1 kDa	No	0
MLLT3-201 ENSP00000486193 ENST00000629733	A0A0D9SF09 [Direct mapping] Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 3, isoform CRA_a; Protein AF-9 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0006355 [regulation of transcription, DNA-templated] Show all	138 aa 15.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.