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Malignant tissues exhibited moderate to strong granular cytoplasmic immunoreactivity accompanied with nuclear or nucleolar staining.
GENE INFORMATION
Gene name
IFNB1 (HGNC Symbol)
Synonyms
IFB, IFF, IFNB
Description
Interferon, beta 1, fibroblast (HGNC Symbol)
Entrez gene summary
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]