Expression of RNASEH1 in cancer - Summary

CANCER ATLAS

Gene description

Ribonuclease H1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA043037

GENE INFORMATION
Gene name	RNASEH1
Synonyms
Description	Ribonuclease H1 (HGNC Symbol)
Entrez gene summary	This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. [provided by RefSeq, Sep 2014]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	3544793 - 3558616
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171865 (version 83.38)
Entrez gene	246243
UniProt	O60930 (UniProt - Evidence at protein level)
neXtProt	NX_O60930
Antibodypedia	RNASEH1 antibodies

PROTEIN BROWSER

RNASEH1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASEH1-001 ENSP00000313350 ENST00000315212	O60930 [Direct mapping] Ribonuclease H1 E5KN15 [Target identity:100%; Query identity:100%] Ribonuclease H1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0004540 [ribonuclease activity] GO:0005739 [mitochondrion] GO:0006401 [RNA catabolic process] GO:0043137 [DNA replication, removal of RNA primer] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	286 aa 32.1 kDa	Yes	0