Expression of ADRA1D in cancer - Summary

CANCER ATLAS

Gene description

Adrenoceptor alpha 1D

Protein class

FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038789

GENE INFORMATION
Gene name	ADRA1D (HGNC Symbol)
Synonyms	ADRA1, ADRA1A, ADRA1R
Description	Adrenoceptor alpha 1D (HGNC Symbol)
Entrez gene summary	Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	4220631 - 4249074
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000171873 (version 83.38)
Entrez gene	146
UniProt	P25100 (UniProt - Evidence at transcript level)
neXtProt	NX_P25100
Antibodypedia	ADRA1D antibodies

PROTEIN BROWSER

ADRA1D-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADRA1D-001 ENSP00000368766 ENST00000379453	P25100 [Direct mapping] Alpha-1D adrenergic receptor B0ZBE0 [Target identity:100%; Query identity:100%] Adrenergic, alpha-1D-, receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Show all	GO:0001986 [negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure] GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure] GO:0004930 [G-protein coupled receptor activity] GO:0004937 [alpha1-adrenergic receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006259 [DNA metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007267 [cell-cell signaling] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0045907 [positive regulation of vasoconstriction] GO:0045987 [positive regulation of smooth muscle contraction] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway] Show all	572 aa 60.5 kDa	No	7