Cell atlas - USP19 - The Human Protein Atlas

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USP19

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	USP19
Gene description	Ubiquitin specific peptidase 19
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	USP19 (HGNC Symbol)
Synonyms	KIAA0891, ZMYND9
Description	Ubiquitin specific peptidase 19 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49108046 - 49120938
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172046 (version 83.38)
Entrez gene	10869
UniProt	O94966 (UniProt - Evidence at protein level)
neXtProt	NX_O94966
Antibodypedia	USP19 antibodies

PROTEIN BROWSER

USP19-001	USP19-002	USP19-004	USP19-005	USP19-006	USP19-012	USP19-013	USP19-014	USP19-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP19-001 ENSP00000381863 ENST00000398888	O94966 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031647 [regulation of protein stability] GO:0034976 [response to endoplasmic reticulum stress] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0048642 [negative regulation of skeletal muscle tissue development] GO:0050821 [protein stabilization] GO:0051879 [Hsp90 protein binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0090068 [positive regulation of cell cycle process] GO:1900037 [regulation of cellular response to hypoxia] GO:1904292 [regulation of ERAD pathway] Show all	1318 aa 145.6 kDa	No	1
USP19-002 ENSP00000381867 ENST00000398892	B5MEG5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1358 aa 149.8 kDa	No	1
USP19-004 ENSP00000381870 ENST00000398896	E7ESU0 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1180 aa 130.9 kDa	No	0
USP19-005 ENSP00000381872 ENST00000398898	E7EST9 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1321 aa 145.6 kDa	No	0
USP19-006 ENSP00000428539 ENST00000479073	H0YB23 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0016579 [protein deubiquitination] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	120 aa 12.7 kDa	No	0
USP19-012 ENSP00000395260 ENST00000417901	O94966 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031647 [regulation of protein stability] GO:0034976 [response to endoplasmic reticulum stress] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0048642 [negative regulation of skeletal muscle tissue development] GO:0050821 [protein stabilization] GO:0051879 [Hsp90 protein binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0090068 [positive regulation of cell cycle process] GO:1900037 [regulation of cellular response to hypoxia] GO:1904292 [regulation of ERAD pathway] Show all	1384 aa 151.9 kDa	No	0
USP19-013 ENSP00000400090 ENST00000453664	O94966 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031647 [regulation of protein stability] GO:0034976 [response to endoplasmic reticulum stress] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0048642 [negative regulation of skeletal muscle tissue development] GO:0050821 [protein stabilization] GO:0051879 [Hsp90 protein binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0090068 [positive regulation of cell cycle process] GO:1900037 [regulation of cellular response to hypoxia] GO:1904292 [regulation of ERAD pathway] Show all	1372 aa 150.7 kDa	No	0
USP19-014 ENSP00000401197 ENST00000434032	O94966 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0031647 [regulation of protein stability] GO:0034976 [response to endoplasmic reticulum stress] GO:0036459 [ubiquitinyl hydrolase activity] GO:0046872 [metal ion binding] GO:0048642 [negative regulation of skeletal muscle tissue development] GO:0050821 [protein stabilization] GO:0051879 [Hsp90 protein binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] GO:0090068 [positive regulation of cell cycle process] GO:1900037 [regulation of cellular response to hypoxia] GO:1901799 [negative regulation of proteasomal protein catabolic process] GO:1904292 [regulation of ERAD pathway] GO:1990380 [Lys48-specific deubiquitinase activity] Show all	1419 aa 156 kDa	No	1
USP19-016 ENSP00000303503 ENST00000306026	A0A0A0MR08 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0016579 [protein deubiquitination] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	569 aa 60.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.