Tissue expression of KLF11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLF11
Gene description	Kruppel-like factor 11
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	KLF11 (HGNC Symbol)
Synonyms	MODY7, TIEG2, Tieg3
Description	Kruppel-like factor 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10042849 - 10054836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172059 (version 83.38)
Entrez gene	8462
UniProt	O14901 (UniProt - Evidence at protein level)
neXtProt	NX_O14901
Antibodypedia	KLF11 antibodies

PROTEIN BROWSER

KLF11-001	KLF11-002	KLF11-003	KLF11-004	KLF11-201	KLF11-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLF11-001 ENSP00000307023 ENST00000305883	O14901 [Direct mapping] Krueppel-like factor 11 Q53QU8 [Target identity:100%; Query identity:100%] Putative uncharacterized protein TIEG2; cDNA FLJ77882, highly similar to Homo sapiens kruppel-like fetal and embryonic globin gene activator (FKLF) mRNA Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	512 aa 55.1 kDa	No	0
KLF11-002 ENSP00000386058 ENST00000401510	B5MCC4 [Direct mapping] Krueppel-like factor 11 Show all	Predicted intracellular proteins Show all		127 aa 13.8 kDa	No	0
KLF11-003 ENSP00000387866 ENST00000448523	E7EX78 [Direct mapping] Krueppel-like factor 11 Show all	Predicted intracellular proteins Show all		163 aa 17.4 kDa	No	0
KLF11-004 ENSP00000388263 ENST00000440320	C9JM94 [Direct mapping] Krueppel-like factor 11 Show all	Predicted intracellular proteins Show all		122 aa 13.3 kDa	No	0
KLF11-201 ENSP00000442722 ENST00000535335	O14901 [Direct mapping] Krueppel-like factor 11 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0046872 [metal ion binding] Show all	495 aa 53.3 kDa	No	0
KLF11-202 ENSP00000444690 ENST00000540845	O14901 [Direct mapping] Krueppel-like factor 11 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0046872 [metal ion binding] Show all	495 aa 53.3 kDa	No	0