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NME6

CANCER ATLAS

Gene description

 NME/NM23 nucleoside diphosphate kinase 6

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA017909

GENE INFORMATION

Gene name

 NME6 (HGNC Symbol)

Synonyms

 IPIA-ALPHA, NM23-H6

Description

 NME/NM23 nucleoside diphosphate kinase 6 (HGNC Symbol)

Entrez gene summary

 Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48293264 - 48301685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172113 (version 83.38)

Entrez gene

 10201

UniProt

 O75414 (UniProt - Evidence at protein level)

neXtProt

 NX_O75414

Antibodypedia

 NME6 antibodies

PROTEIN BROWSER
«
NME6-001
NME6-002
NME6-005
NME6-006
NME6-007
NME6-012
NME6-014
NME6-015
NME6-016
NME6-017
NME6-018
NME6-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NME6-001
ENSP00000416658
ENST00000421967
A0A0C4DG91 [Direct mapping]
Nucleoside diphosphate kinase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 194 aa
22 kDa 		No 0
NME6-002
ENSP00000394232
ENST00000415644
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 119 aa
13.5 kDa 		No 0
NME6-005
ENSP00000392352
ENST00000452211
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 186 aa
21.1 kDa 		No 0
NME6-006
ENSP00000407933
ENST00000451657
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 163 aa
18.1 kDa 		No 0
NME6-007
ENSP00000406642
ENST00000442597
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 186 aa
21.1 kDa 		No 0
NME6-012
ENSP00000414842
ENST00000447314
C9JQB1 [Direct mapping]
Nucleoside diphosphate kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 141 aa
16.2 kDa 		No 0
NME6-014
ENSP00000393261
ENST00000435684
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 163 aa
18.1 kDa 		No 0
NME6-015
ENSP00000392715
ENST00000456495
C9J1J2 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 111 aa
13.1 kDa 		No 0
NME6-016
ENSP00000411116
ENST00000425930
C9J9V6 [Direct mapping]
Nucleoside diphosphate kinase
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 174 aa
20.1 kDa 		No 0
NME6-017
ENSP00000399582
ENST00000415053
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 186 aa
21.1 kDa 		No 0
NME6-018
ENSP00000405755
ENST00000447724
C9J867 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005622 [intracellular]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
Show all
 61 aa
7.1 kDa 		No 0
NME6-201
ENSP00000440286
ENST00000426689
O75414 [Direct mapping]
Nucleoside diphosphate kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006183 [GTP biosynthetic process]
GO:0006228 [UTP biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006915 [apoptotic process]
GO:0030308 [negative regulation of cell growth]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0046872 [metal ion binding]
Show all
 186 aa
21.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.