Fields »
ABOUT
HELP
BLOG
CYCS

CANCER ATLAS

Gene description

 Cytochrome c, somatic

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004222
CAB005126
CAB018597

GENE INFORMATION

Gene name

 CYCS (HGNC Symbol)

Synonyms

 CYC, HCS

Description

 Cytochrome c, somatic (HGNC Symbol)

Entrez gene summary

 This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 p15.3

Chromosome location (bp)

 25120091 - 25125361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172115 (version 83.38)

Entrez gene

 54205

UniProt

 P99999 (UniProt - Evidence at protein level)

neXtProt

 NX_P99999

Antibodypedia

 CYCS antibodies

PROTEIN BROWSER
CYCS-001
CYCS-002
CYCS-003
CYCS-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYCS-001
ENSP00000307786
ENST00000305786
P99999 [Direct mapping]
Cytochrome c
G4XXL9 [Target identity:100%; Query identity:100%]
Cytochrome c; Cytochrome c, somatic, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000302 [response to reactive oxygen species]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity]
GO:0045333 [cellular respiration]
GO:0046872 [metal ion binding]
GO:0070469 [respiratory chain]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 105 aa
11.7 kDa 		No 0
CYCS-002
ENSP00000386270
ENST00000409409
P99999 [Direct mapping]
Cytochrome c
G4XXL9 [Target identity:100%; Query identity:100%]
Cytochrome c; Cytochrome c, somatic, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000302 [response to reactive oxygen species]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity]
GO:0045333 [cellular respiration]
GO:0046872 [metal ion binding]
GO:0070469 [respiratory chain]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 105 aa
11.7 kDa 		No 0
CYCS-003
ENSP00000387279
ENST00000409764
P99999 [Direct mapping]
Cytochrome c
G4XXL9 [Target identity:100%; Query identity:100%]
Cytochrome c; Cytochrome c, somatic, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0000302 [response to reactive oxygen species]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0009055 [electron carrier activity]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0020037 [heme binding]
GO:0022904 [respiratory electron transport chain]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity]
GO:0045333 [cellular respiration]
GO:0046872 [metal ion binding]
GO:0070469 [respiratory chain]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 105 aa
11.7 kDa 		No 0
CYCS-004
ENSP00000416479
ENST00000413447
C9JFR7 [Direct mapping]
Cytochrome c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0009055 [electron carrier activity]
GO:0020037 [heme binding]
GO:0042773 [ATP synthesis coupled electron transport]
GO:0046872 [metal ion binding]
GO:0070469 [respiratory chain]
Show all
 101 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.