Expression of MRPL13 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L13

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA060899

GENE INFORMATION
Gene name	MRPL13 (HGNC Symbol)
Synonyms	L13, L13A, L13mt, RPL13, RPML13
Description	Mitochondrial ribosomal protein L13 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.12
Chromosome location (bp)	120380761 - 120445402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172172 (version 83.38)
Entrez gene	28998
UniProt	Q9BYD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYD1
Antibodypedia	MRPL13 antibodies

PROTEIN BROWSER

MRPL13-001	MRPL13-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL13-001 ENSP00000306548 ENST00000306185	Q9BYD1 [Direct mapping] 39S ribosomal protein L13, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	178 aa 20.7 kDa	No	0
MRPL13-005 ENSP00000430545 ENST00000518918	E5RJI7 [Direct mapping] 39S ribosomal protein L13, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	148 aa 17.1 kDa	No	0