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DPAGT1

GENERAL INFORMATION

Gene name

 DPAGT1

Gene description

 Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, often in a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053878
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DPAGT1 (HGNC Symbol)

Synonyms

 ALG7, CDG-Ij, D11S366, DGPT, DPAGT, DPAGT2, GPT

Description

 Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 119096503 - 119108331

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172269 (version 83.38)

Entrez gene

 1798

UniProt

 Q9H3H5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3H5

Antibodypedia

 DPAGT1 antibodies

PROTEIN BROWSER
DPAGT1-001
DPAGT1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPAGT1-001
ENSP00000346142
ENST00000354202
Q9H3H5 [Direct mapping]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
A0A024R3H8 [Target identity:100%; Query identity:100%]
Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003975 [UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006047 [UDP-N-acetylglucosamine metabolic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008963 [phospho-N-acetylmuramoyl-pentapeptide-transferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019408 [dolichol biosynthetic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051259 [protein oligomerization]
Show all
 408 aa
46.1 kDa 		No >9
DPAGT1-002
ENSP00000386597
ENST00000409993
Q9H3H5 [Direct mapping]
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
A0A024R3H8 [Target identity:100%; Query identity:100%]
Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003975 [UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006047 [UDP-N-acetylglucosamine metabolic process]
GO:0006487 [protein N-linked glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008963 [phospho-N-acetylmuramoyl-pentapeptide-transferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019348 [dolichol metabolic process]
GO:0019408 [dolichol biosynthetic process]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0051259 [protein oligomerization]
Show all
 408 aa
46.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.