Cell atlas - SUCLG2 - The Human Protein Atlas

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SUCLG2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Plasma membrane

Human cell
	Mitochondria
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SUCLG2
Gene description	Succinate-CoA ligase, GDP-forming, beta subunit
Protein class	Citric acid cycle related proteins Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Mitochondria (supported)
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046705
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & mitochondria.

Main location

Plasma membrane (approved), Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046705	A-431	Plasma membrane
	HPA046705	A-431	Mitochondria
	HPA046705	Hep G2	Mitochondria
	HPA046705	U-2 OS	Plasma membrane

MOUSE CELLS

Main location

Mitochondria

Mouse gene

ENSMUSG00000061838 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA046705	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	SUCLG2
Synonyms
Description	Succinate-CoA ligase, GDP-forming, beta subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	67360460 - 67654614
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172340 (version 83.38)
Entrez gene	8801
UniProt	Q96I99 (UniProt - Evidence at protein level)
neXtProt	NX_Q96I99
Antibodypedia	SUCLG2 antibodies

PROTEIN BROWSER

SUCLG2-001	SUCLG2-002	SUCLG2-003	SUCLG2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUCLG2-001 ENSP00000307432 ENST00000307227	Q96I99 [Direct mapping] Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial A0A024R325 [Target identity:100%; Query identity:100%] Succinyl-CoA ligase subunit beta Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004776 [succinate-CoA ligase (GDP-forming) activity] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006099 [tricarboxylic acid cycle] GO:0006104 [succinyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	432 aa 46.5 kDa	No	0
SUCLG2-002 ENSP00000419325 ENST00000493112	Q96I99 [Direct mapping] Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004776 [succinate-CoA ligase (GDP-forming) activity] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005886 [plasma membrane] GO:0006099 [tricarboxylic acid cycle] GO:0006104 [succinyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] Show all	440 aa 47.7 kDa	No	0
SUCLG2-003 ENSP00000417589 ENST00000492795	E9PDQ8 [Direct mapping] Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] Show all	379 aa 41.4 kDa	No	0
SUCLG2-004 ENSP00000417260 ENST00000460567	H0Y852 [Direct mapping] Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] Show all	190 aa 20.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.